Effects of the Nitric Oxide Synthase Inhibitor L-name on Recognition and Spatial Memory Deficits Produced by Different Nmda Receptor Antagonist in the Rat
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چکیده
EFFECTS OF THE NITRIC OXIDE SYNTHASE INHIBITOR L-NAME ON RECOGNITION AND SPATIAL MEMORY DEFICITS PRODUCED BY DIFFERENT NMDA RECEPTOR ANTAGONIST IN THE RAT Antonios Boultadakis and Nikolaos Pitsikas* Department of Pharmacology, School of Medicine, University of Thessaly, Larissa, Greece *Correspondence to: N. Pitsikas. Department of Pharmacology, School of Medicine, University of Thessaly, Biopolis, 411-10 Larissa, Greece e-mail: [email protected]; Phone: +30-2410-685535; Fax: +302410-685552 Running title: effects of L-NAME on NMDA blockade
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Background and Objective: Nitric oxide mediated some behavioral effects of nicotine and ethanol in the nucleus accumbens. In the present study, the effects of L-NAME (nitric oxide synthase inhibitor) in the nucleus accumbens on nicotine’s effect in ethanol-induced amnesia were investigated. Materials and Methods: In this experimental study 96 adult male wistar rats were used (12 groups)...
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تاریخ انتشار 2010